Potassium Carbonate → HCID 21270429, compound

HRID 1194540Notes

Reaction equation

HRID 1194540 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:6][O:7][C:8]([N:10]1[CH2:14][CH2:13][C:12](=O)[CH2:11]1)=[O:9].C(=O)([O-])[O-].[K+].[K+]>CCOCC.C1(C)C=CC=CC=1>[N:1]1([C:12]2[CH2:11][N:10]([C:8]([O:7][CH3:6])=[O:9])[CH2:14][CH:13]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 31268PyrrolidineHCID 12430955Methyl 3-oxopyrrolidine-1-carboxylate

Product 1

HCID 21270429HCID 21270429, compound

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 3283Diethyl EtherSolvent

Procedure

Pyrrolidine (25 ml) is slowly added dropwise to a stirred suspension of 28.63 g of N-methoxycarbonyl-3-oxo-tetrahydropyrrole [prepared according to J Med Chem 5, 752 (1962)] and 29.5 g of anhydrous potassium carbonate in 200 ml ether and 100 ml toluene at 0°-5° under a nitrogen atmosphere. After 3 hours the suspension is filtered and the filtrate evaporated under reduced pressure to yield 3-pyrrolidino-N-methoxycarbonyl-2,5-dihydropyrrole as an oil. NMR (CDCl3): 4.12 (s), 4.01 (m), 3.63 (s), 3.00 (m), and 1.85 (m).

Workup

  1. filtrationAfter 3 hours the suspension is filtered
  2. customthe filtrate evaporated under reduced pressure

Sources & evidence

ORD record
ord-ed08edb67ded434ebc33661366155f00
Source dataset
uspto-grants-1989_03
Patent number
US04814450

Reaction notes

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