Urea → HCID 53784406, compound

HRID 1194542Notes

Reaction equation

HRID 1194542 reaction equation
[CH3:1][O:2][C:3]([N:5]1[CH2:9][C:8]([N:10]2[CH2:14][CH2:13][CH2:12][CH2:11]2)=[C:7]([C:15]([O:17]CC)=O)[CH:6]1C(=O)C)=[O:4].CO[CH:25](OC)[N:26]([CH3:28])[CH3:27].NC(N)=[O:33].[O:35]1[CH2:40][CH2:39]O[CH2:37][CH2:36]1>>[CH3:1][O:2][C:3]([N:5]1[CH2:9][C:8]([N:10]2[CH2:11][CH2:12][CH2:13][CH2:14]2)=[C:7]([C:15](=[O:17])[C:37]([C:36]([O:35][CH2:40][CH3:39])=[O:33])=[CH:25][N:26]([CH3:27])[CH3:28])[CH2:6]1)=[O:4]

Participants

5

Reactant 4

HCID 1176UreaHCID 312751,4-DioxaneHCID 78373Dimethylformamide dimethyl acetalHCID 70393673HCID 70393673, compound

Product 1

HCID 53784406HCID 53784406, compound

Procedure

A solution of 12.41 g of N-methoxycarbonyl-3-carboethoxy-acetyl-4-pyrrolidino-2,5-dihydropyrrole, 9.64 ml of N,N-dimethylformamide dimethylacetal and 10 mg of urea in 50 ml of dioxane is stirred under nitrogen for 16 hours. Evaporation of the solvent yields N-methoxycarbonyl-3-(2-ethoxycarbonyl-3-dimethylaminoacryloyl)-4-pyrrolidino-2,5-dihydropyrrole as an oil.

Workup

  1. customEvaporation of the solvent

Sources & evidence

ORD record
ord-f13ecc9124624e6aa609549778ce5cbb
Source dataset
uspto-grants-1989_03
Patent number
US04814450

Reaction notes

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