Ici 109,081 → HCID 13749451, compound

HRID 1194676Notes

Reaction equation

HRID 1194676 reaction equation
[O:1]=[C:2]1[CH2:8][CH2:7][S:6][CH2:5][CH:4]([C:9]([OH:11])=O)[NH:3]1.[NH2:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:20]([CH3:26])[CH2:21][C:22](=[O:25])[NH:23][N:24]=2)=[CH:15][CH:14]=1>CN(C)C=O>[O:1]=[C:2]1[CH2:8][CH2:7][S:6][CH2:5][CH:4]([C:9]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]3[CH:20]([CH3:26])[CH2:21][C:22](=[O:25])[NH:23][N:24]=3)=[CH:15][CH:14]=2)=[O:11])[NH:3]1

Participants

4

Reactant 2

HCID 161928Ici 109,081HCID 14442188HCID 14442188, compound

Product 1

HCID 13749451HCID 13749451, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

5.3 g (0.03 mole) of 5-oxo-perhydro-(1,4)-thiazepine-3-carboxylic acid and 6.1 g (0.03 mole) of N,N'-carbonyl-diimidazole are stirred in 15 ml of dimethylformamide at 50° c. for 15 minutes. After addition of 4.9 g (0.03 mole) of 6-(4-amino-phenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone, the mixture is stirred at room temperature for 12 hours and the product is filtered off with suction and dried.

Workup

  1. filtrationthe product is filtered off with suction
  2. customdried

Sources & evidence

ORD record
ord-368e779c63ad457a9973fb66ddf11ded
Source dataset
uspto-grants-1989_03
Patent number
US04816454

Reaction notes

Loading…