Acetonitrile → HCID 15631955, compound

HRID 1194689Notes

Reaction equation

HRID 1194689 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][NH:8][CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.C([O-])([O-])=O.[K+].[K+].C(#N)C.Br[CH2:21][CH2:22][CH2:23][CH3:24]>O>[CH2:21]([N:8]1[CH2:9][CH2:10][C:5]2([O:4][CH2:3][CH2:2][O:1]2)[CH2:6][CH2:7]1)[CH2:22][CH2:23][CH3:24]

Participants

6

Reactant 4

HCID 6342AcetonitrileHCID 8002Butyl bromideHCID 11430Potassium CarbonateHCID 674351,4-Dioxa-8-azaspiro(4.5)decane

Product 1

HCID 15631955HCID 15631955, compoundYield 556.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a mixture of 15 g (0.015 mol) of 1,4-dioxa-8-azaspiro[4.5]decane, 15.93 g (0.115 mol) of K2CO3, and 100 ml of acetonitrile is added drowpwise 11.25 ml (0.105 mol) of 1-bromobutane. The mixture is stirred overnight at room temperature and then at 65° C. for 2 hours. After cooling, the mixture is diluted with water and extracted with methylene chloride. The combined extracts are washed with brine, dried over Na2SO4, and concentrated in vacuo to yield 16.63 g (80%) of the title compound as a yellow liquid: IR (neat) 2959 and 1092 cm-1 ; NMR (CDCl3)δ3.97 (s, 4H), 2.56 (s, 4H), 2.38 (m, 2H), 1.77 (t, 4H), 1.49 (m, 2H), 1.34 (m, 2H), 0.92 (t, 3H).

Workup

  1. waitat 65° C. for 2 hours
  2. temperatureAfter cooling
  3. extractionextracted with methylene chloride
  4. washThe combined extracts are washed with brine
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-96c3b9ed09a24fe8907545d9374cce2b
Source dataset
uspto-grants-1989_03
Patent number
US04816464

Reaction notes

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