Hydrochloric Acid → HCID 21268839, compound

HRID 1194776Notes

Reaction equation

HRID 1194776 reaction equation
[CH2:1]([N:4]([CH2:14][CH2:15][CH3:16])[CH:5]1[CH2:10][S:9][C:8]2[S:11][CH:12]=[CH:13][C:7]=2[CH2:6]1)[CH2:2][CH3:3].[ClH:17]>COC(C)(C)C>[ClH:17].[CH2:14]([N:4]([CH2:1][CH2:2][CH3:3])[CH:5]1[CH2:10][S:9][C:8]2[S:11][CH:12]=[CH:13][C:7]=2[CH2:6]1)[CH2:15][CH3:16]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21268838HCID 21268838, compound

Product 1

HCID 21268839HCID 21268839, compound

Reagents, catalysts & solvents 1

HCID 15413tert-Butyl methyl etherSolvent2×

Procedure

A solution of 4.0 g of N,N-dipropyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-5-amine in 20 ml of t-butyl methyl ether is slowly added while stirring to a mixture of 5.42 g of 2.4 M ethanolic hydrogen chloride in 45 ml of t-butyl methyl ether. The crystalline product is collected, washed with the solvent and dried to give N,N-dipropyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-5-amine hydrochloride, m.p. 163°-167°.

Workup

  1. customThe crystalline product is collected
  2. washwashed with the solvent
  3. customdried

Sources & evidence

ORD record
ord-d760360f1b8b4889895e12a01990f81a
Source dataset
uspto-grants-1989_03
Patent number
US04816474

Reaction notes

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