反应详情

A mixture of 55 mg (0.2 mmole) of 9-(1,3-dihydroxy-2-propoxymethyl)guanine monohydrate, 130 mg (0.8 mmole) of 1,1'-carbonyldiimidazole, and 2 ml of dry dimethylformamide was stirred under nitrogen at 95°-100° for 1.5 hours, during which time a clear solution was obtained followed by precipitation of product. After cooling, the precipitate was collected on a filter and washed with some dimethylformamide and then with acetone to give 37 mg of white crystals, m.p. 252°-253° dec. The NMR spectrum was in accord with the assigned structure.

1. customwas obtained
2. customfollowed by precipitation of product
3. temperatureAfter cooling
4. customthe precipitate was collected on
5. filtrationa filter
6. washwashed with some dimethylformamide