反应详情

Morpholine (1.5 ml), 2,3-dihydro-5-acetylbenzofuran (2.0 g), sulfur (0.395 g) and p-toluene sulfonic acid (0.060 g) were heated at reflux After 3 hours, the reaction mixture was cooled and 6 ml of methanol added. This solution was further cooled which precipitated the morpholide. The precipitate was filtered and washed with cold methanol to give 2,3-dihydrobenzofuran-5-ylthioacetic acid morpholide, m.p. --144°-147° C.

1. temperatureat reflux After 3 hours
2. temperaturethe reaction mixture was cooled
3. temperatureThis solution was further cooled which
4. customprecipitated the morpholide
5. filtrationThe precipitate was filtered
6. washwashed with cold methanol