Diethyl Ether → HCID 18631454, compound

HRID 1194969Notes

Reaction equation

HRID 1194969 reaction equation
C([O:5][C:6](=[O:37])[CH2:7][N:8]([C:18](=[O:36])[C@H:19]([CH3:35])[NH:20][C@H:21]([C:32]([OH:34])=[O:33])[CH2:22][CH2:23][CH2:24][CH2:25][CH:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1)[CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH2:10]1)(C)(C)C.C(OCC)(=O)C.[ClH:44].C(OCC)C>C(O)(=O)C.C(OCC)(=O)C>[ClH:44].[ClH:44].[C:32]([C@@H:21]([NH:20][C@H:19]([C:18]([N:8]([CH:9]1[CH2:10][C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:17]1)[CH2:7][C:6]([OH:37])=[O:5])=[O:36])[CH3:35])[CH2:22][CH2:23][CH2:24][CH2:25][CH:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1)([OH:34])=[O:33]

Participants

6

Reactant 3

HCID 3283Diethyl EtherHCID 21866389Hydrogen chloride-ethyl acetateHCID 54438115HCID 54438115, compound

Product 1

HCID 18631454HCID 18631454, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 8857Ethyl AcetateSolvent

Procedure

In a mixture of 2 ml of acetic acid and 2 ml of ethyl acetate is dissolved 0.28 g of N-[N-[(S)-5-(4-piperidyl)-1-carboxypentyl]-L-alanyl]-N-(indan-2-yl)glycine tert-butyl ester, and 5 ml of 5N hydrogen choride-ethyl acetate solution is added to the solution, followed by standing at room temperature for 1 hour. 100 ml of ethyl ether is added to the reaction solution, and the precipitate which separates out is colleted by filtration to give 0.22 g of N-[N-[(S)-1-carboxy-5-(4-piperidyl)pentyl]-L-alanyl]-N-(indan-2yl)glycine.dihydrochloride as a colorless powder.

Workup

  1. additionis added to the solution
  2. filtrationthe precipitate which separates out is colleted by filtration

Sources & evidence

ORD record
ord-c68cd8fc43ab4820bda71d9197d945bb
Source dataset
uspto-grants-1989_03
Patent number
US04816466

Reaction notes

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