Hydrochloric Acid → HCID 178418600, compound

HRID 1194986Notes

Reaction equation

HRID 1194986 reaction equation
Cl.CC(O)=O.CO.[NH:8](C(OC(C)(C)C)=O)[C@H:9]([C:17]([OH:19])=[O:18])[CH2:10][CH2:11][CH2:12][NH:13][C:14](=[NH:16])[NH2:15].Cl>C(O)(C)C>[NH2:8][C@H:9]([C:17]([OH:19])=[O:18])[CH2:10][CH2:11][CH2:12][NH:13][C:14](=[NH:15])[NH2:16]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 22641269Acetate-hydrochloric acidHCID 178454187HCID 178454187, compound

Product 1

HCID 178418600HCID 178418600, compoundYield 163%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Into a mixture consisting of 1,093 ml of 2N HCl/AcOH and a small quantity of MeOH was dissolved 243.7 g (0.55 mole) of BOC-Arg-CHA.HCl, and the resulting solution was reacted at room temperature for one hour. After the reaction, 1,093 ml of isopropyl alcohol was added, and the product was re-precipitated in AcOEt. The deposited crystalline product was collected by filtration and dried to obtain 156.2 g (74.3%) of H-Arg-CHA.2HCl.

Workup

  1. additionwas added
  2. customthe product was re-precipitated in AcOEt
  3. filtrationThe deposited crystalline product was collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-e0343e6ff11341ed80257f14ef59b12f
Source dataset
uspto-grants-1989_03
Patent number
US04816562

Reaction notes

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