Hydrochloric Acid → HCID 178453393, compound

HRID 1194989Notes

Reaction equation

HRID 1194989 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@@H:2]([C:15]([NH:17][C@H:18]([C:26]([NH:28][C@H:29]([C:37]([OH:39])=[O:38])[CH2:30][CH2:31][CH2:32][NH:33][C:34](=[NH:36])[NH2:35])=[O:27])[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:16])[CH2:3][CH2:4][CH2:5][CH2:6][NH:7][C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9].Cl>[Pd].CO>[NH2:1][C@@H:2]([C:15]([NH:17][C@H:18]([C:26]([NH:28][C@H:29]([C:37]([OH:39])=[O:38])[CH2:30][CH2:31][CH2:32][NH:33][C:34](=[NH:35])[NH2:36])=[O:27])[CH2:19][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)=[O:16])[CH2:3][CH2:4][CH2:5][CH2:6][NH:7][C:8]([O:10][C:11]([CH3:13])([CH3:14])[CH3:12])=[O:9]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178453395HCID 178453395, compound

Product 1

HCID 178453393HCID 178453393, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Into 75 ml of MeOH was dissolved 8.9 g (10.4 mmoles) of Z-D-Lys(BOC)-Phe-Arg-CHA.HCl. After adding 1 gram of palladium black, it was catalytically reduced at 30° C. for 8 hours. After the reaction, the catalyst was filtered off and the solvent was distilled off under reduced pressure. Thus, 6.4 g (85.3%; a foamed product) of H-D-Lys(BOC)-Phe-Arg-CHA.2HCl was obtained.

Workup

  1. customAfter the reaction
  2. filtrationthe catalyst was filtered off
  3. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-f9f7e2a047154ffcb5b5958a8ea5f8f2
Source dataset
uspto-grants-1989_03
Patent number
US04816562

Reaction notes

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