Potassium Carbonate → HCID 54067527, compound

HRID 1195133Notes

Reaction equation

HRID 1195133 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH2:9][CH2:10][CH2:11][NH2:12])=[CH:4][CH:3]=1.[CH2:20]([O:22][C:23](=[O:27])[CH2:24][CH2:25]Br)[CH3:21].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[CH2:20]([O:22][C:23](=[O:27])[CH2:24][CH2:25][NH:12][CH2:11][CH2:10][CH2:9][CH:8]([C:13]1[CH:14]=[CH:15][C:16]([F:19])=[CH:17][CH:18]=1)[C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1)[CH3:21]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 68320Ethyl 3-bromopropionateHCID 13530069HCID 13530069, compound

Product 1

HCID 54067527HCID 54067527, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

26.1 g (0.1 mol) of 4,4-di(p-fluorophenyl)butylamine and 18.1 g of 3-bromopropionic acid ethyl ester are refluxed with 21.0 g of potassium carbonate in 200 ml of 2-butanone for 24 hours while stirring. The reaction mixture is filtered and the filtrate is concentrated by evaporation under reduced pressure, yielding crude 3-[4,4-di(p-fluorophenyl)-butylamino]-propionic acid ethyl ester in the form of an oil.

Workup

  1. filtrationThe reaction mixture is filtered
  2. concentrationthe filtrate is concentrated by evaporation under reduced pressure

Sources & evidence

ORD record
ord-4c2e0af4cd0d47ff8297408e9d49868b
Source dataset
uspto-grants-1992_05
Patent number
US05110807

Reaction notes

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