Methylamine → HCID 53975244, compound

HRID 1195436Notes

Reaction equation

HRID 1195436 reaction equation
Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])=[CH:4][N:3]=1.[CH3:19][NH2:20]>>[F:18][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[CH2:11][N:8]1[CH:7]=[N:6][C:5]2[C:9]1=[N:10][C:2]([NH:20][CH3:19])=[N:3][CH:4]=2

Participants

3

Reactant 2

HCID 6329MethylamineHCID 24904076HCID 24904076, compound

Product 1

HCID 53975244HCID 53975244, compound

Procedure

In a manner analogous to that described in Example 2 it is also possible, by reacting 2-chloro-9-(2-fluorobenzyl)-9H-purine (Example 7) with N-methylamine, to obtain the 9-(2-fluorobenzyl)-2-(N-methylamino)-9H-purine, which has a melting range of from 184° to 185° (methanol/diethyl ether), the reaction mixture being heated for 24 hours at from 80° to 85°.

Sources & evidence

ORD record
ord-414d419ea0c241fe8bdccf3f2a684ba3
Source dataset
uspto-grants-1992_05
Patent number
US05110818

Reaction notes

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