Butyl nitrite → HCID 22843826, compound

HRID 1195727Notes

Reaction equation

HRID 1195727 reaction equation
[OH:1][C@@H:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C@H:3]1[O:11][C:12]1[C:13]2[N:14]([CH:18]=[C:19]([CH3:21])[N:20]=2)[CH:15]=[CH:16][CH:17]=1.[N:22](OCCCC)=[O:23]>O1CCCC1>[OH:1][C@@H:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C@H:3]1[O:11][C:12]1[C:13]2[N:14]([C:18]([N:22]=[O:23])=[C:19]([CH3:21])[N:20]=2)[CH:15]=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 10996Butyl nitriteHCID 22843827HCID 22843827, compound

Product 1

HCID 22843826HCID 22843826, compoundYield 63.4%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.5 g 8-(2-(trans)-hydroxy-2,3-dihydro-1-indenyloxy)-2-methyl-imidazo[1,2-a]pyridine, dissolved in 50 ml tetrahydrofuran, are mixed with 0.6 g commercial butyl nitrite at 50° C. and left over night at this temperature. After evaporation of the volatile components in vacuo, residue is washed with few cold acetonitrile and, after the solvent is poured off, recrystallized from acetonitrile. 0.35 g yellow title compound of m.p. 178°-179° C. is obtained.

Workup

  1. waitleft over night at this temperature
  2. customAfter evaporation of the volatile components in vacuo, residue
  3. washis washed with few cold acetonitrile
  4. additionafter the solvent is poured off
  5. customrecrystallized from acetonitrile

Sources & evidence

ORD record
ord-7192c2be881a41ab9f47c03ad7925578
Source dataset
uspto-grants-1992_05
Patent number
US05112834

Reaction notes

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