Sodium hydride → HCID 14857350, compound

HRID 1195810Notes

Reaction equation

HRID 1195810 reaction equation
[H-].[Na+].[CH3:3][C:4]1([CH3:31])[CH:13](O)[CH:12]([C:15]2[C:16](=[O:28])[N:17]([CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH:18]=[CH:19][CH:20]=2)[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:29]#[N:30])[CH:10]=2)[O:5]1>O1CCOCC1.N#N>[CH3:3][C:4]1([CH3:31])[CH:13]=[C:12]([C:15]2[C:16](=[O:28])[N:17]([CH2:21][C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH:18]=[CH:19][CH:20]=2)[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:29]#[N:30])[CH:10]=2)[O:5]1

Participants

5

Reactant 2

HCID 24758Sodium hydrideHCID 14857308HCID 14857308, compound

Product 1

HCID 14857350HCID 14857350, compound

Reagents, catalysts & solvents 2

HCID 947NitrogenSolventHCID 312751,4-DioxaneSolvent

Procedure

0.4 g of NaH is added to a solution of 1 g of 2,2-dimethyl-4-(1-benzyl-1,2-dihydro-2-oxo-3-pyridyl)-6-cyano-3-chromanol in 40 ml of dioxane while stirring and passing in N2, the mixture is subsequently boiled for 10 hours and evaporated, and the residue is worked up in the customary manner. 2,2-Dimethyl-4-(1-benzyl-1,2-dihydro-2-oxo-3-pyridyl)-6-cyano-3-chromene is obtained, m.p. 130°-132°.

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-e826da9db56f4843a5352dba93c11cdb
Source dataset
uspto-grants-1992_05
Patent number
US05112839

Reaction notes

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