Trifluoroacetic acid → HCID 14368703, compound

HRID 1195833Notes

Reaction equation

HRID 1195833 reaction equation
[C:1]1([C:7](C2C=CC=CC=2)(C2C=CC=CC=2)O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.FC(F)(F)C(O[C:26](=O)[C:27]([F:30])(F)F)=O.[F:34][C:35](F)(F)[C:36](O)=O>>[F:30][C:27]1[CH:26]=[C:35]([F:34])[CH:36]=[C:6]2[C:5]=1[CH:4]=[CH:3][CH:2]=[C:1]2[CH3:7]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 6457TriphenylcarbinolHCID 9845Trifluoroacetic anhydride

Product 1

HCID 14368703HCID 14368703, compound

Procedure

2.5 g of 5,7-Difluoro-1-methyl-tetralol, 3.6 g of triphenylmethanol and 2.6 g of trifluoroacetic acid anhydride are refluxed for 5 hours in 16 ml of trifluoroacetic acid. The mixture is poured onto ice-water and extracted with dichloromethane. The organic phase is washed neutral with sodium bicarbonate solution, dried and concentrated. The oily crude product can be purified by chromatography over silica gel (eluant:hexane).

Workup

  1. additionThe mixture is poured onto ice-water
  2. extractionextracted with dichloromethane
  3. washThe organic phase is washed neutral with sodium bicarbonate solution
  4. customdried
  5. concentrationconcentrated
  6. customThe oily crude product can be purified by chromatography over silica gel (eluant:hexane)

Sources & evidence

ORD record
ord-ad67fd31fe2446d6979950a44886008f
Source dataset
uspto-grants-1992_05
Patent number
US05112851

Reaction notes

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