Iodine → HCID 53739951, compound

HRID 1195837Notes

Reaction equation

HRID 1195837 reaction equation
II.I[CH2:4]I.[C:6]([C:8]1[CH:13]=[CH:12][C:11]([C:14]([C:16]2[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=2)=[CH2:15])=[CH:10][CH:9]=1)#[N:7]>C1(C)C=CC=CC=1.[Cu]>[Cl:22][C:19]1[CH:18]=[CH:17][C:16]([C:14]2([C:11]3[CH:10]=[CH:9][C:8]([C:6]#[N:7])=[CH:13][CH:12]=3)[CH2:4][CH2:15]2)=[CH:21][CH:20]=1

Participants

6

Reactant 3

HCID 807IodineHCID 6346DiiodomethaneHCID 54481297HCID 54481297, compound

Product 1

HCID 53739951HCID 53739951, compound

Reagents, catalysts & solvents 2

HCID 23978CopperCatalystHCID 1140TolueneSolvent

Procedure

600 mg of Copper powder are cauterized with 10 mg of iodine in 10 ml of toluene. 1.2 g of Diiodomethane and 500 mg of 1-(4-cyanophenyl)-1-(4-chlorophenyl)-ethylene are added and the mixture refluxed for 140 hours and then filtered and the filtrate concentrated. The oily residue is chromatographed on silica gel with toluene as eluant.

Workup

  1. temperaturethe mixture refluxed for 140 hours
  2. filtrationfiltered
  3. concentrationthe filtrate concentrated
  4. customThe oily residue is chromatographed on silica gel with toluene as eluant

Sources & evidence

ORD record
ord-cb5f4a7023b642f0ac9b743926db2342
Source dataset
uspto-grants-1992_05
Patent number
US05112851

Reaction notes

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