Aluminium lithium hydride → HCID 53883034, compound

HRID 1195838Notes

Reaction equation

HRID 1195838 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[Cl:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2([C:17]3[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[CH:19][CH:18]=3)[CH2:16][CH2:15]2)=[CH:10][CH:9]=1>O1CCCC1>[Cl:7][C:8]1[CH:9]=[CH:10][C:11]([C:14]2([C:17]3[CH:18]=[CH:19][C:20]([CH2:23][NH2:24])=[CH:21][CH:22]=3)[CH2:15][CH2:16]2)=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 53739951HCID 53739951, compound

Product 1

HCID 53883034HCID 53883034, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

230 mg of Lithiumaluminiumhydride are suspended in 10 ml of tetrahydrofuran, 234 mg of 1-(4-chlorophenyl)-1-(4-cyanophenyl)cyclopropane in 5 ml tetrahydrofuran added dropwise and the mixture refluxed for 18 hours. The mixture is then hydrolysed with 1N HCl and extracted with dichloromethane. The oily title compound is directly reacted further.

Workup

  1. temperaturethe mixture refluxed for 18 hours
  2. extractionhydrolysed with 1N HCl and extracted with dichloromethane
  3. customThe oily title compound is directly reacted further

Sources & evidence

ORD record
ord-a553eb9a2897465f91a8ba39c908d69f
Source dataset
uspto-grants-1992_05
Patent number
US05112851

Reaction notes

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