Lithium Hydroxide → HCID 15027385, compound

HRID 1195882Notes

Reaction equation

HRID 1195882 reaction equation
[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[C:4]([Cl:9])[C:3]=1[NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH:17]([CH3:20])[NH:18][OH:19].[C:21](Cl)(=[O:23])[CH3:22].C(N(CC)CC)C.[OH-].[Li+]>>[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[C:4]([Cl:9])[C:3]=1[NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH:17]([N:18]([OH:19])[C:21](=[O:23])[CH3:22])[CH3:20]

Participants

5

Reactant 4

HCID 3939Lithium HydroxideHCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 54337140HCID 54337140, compound

Product 1

HCID 15027385HCID 15027385, compoundYield 45%

Procedure

2-[(2,6-Dichloro-3-methylphenyl)amino]-N-hydroxy-α-methylbenzenemethanamine (1.2 g, 3.8 mmol) is reacted with acetyl chloride (0.66 g, 8.5 mmol), triethylamine (1.2 g, 11.6 mmol), and lithium hydroxide (0.46 g, 19.3 mmol) according to the procedure of Example 48 to give N-[1-[2-[(2,6-dichloro-3-methylphenyl)amino]phenyl]ethyl]-N-hydroxyacetamide (0.6 g, 45% yield); mp 185°-187° C.

Sources & evidence

ORD record
ord-bcb08ace5d764d7b9ebab56ee86f58e5
Source dataset
uspto-grants-1992_05
Patent number
US05112846

Reaction notes

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