Lithium Hydroxide → HCID 9927844, compound

HRID 1195883Notes

Reaction equation

HRID 1195883 reaction equation
[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[C:4]([Cl:9])[C:3]=1[NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH2:17][NH:18][OH:19].[C:20](Cl)(=[O:22])[CH3:21].C(N(CC)CC)C.[OH-].[Li+]>>[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[C:4]([Cl:9])[C:3]=1[NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH2:17][N:18]([OH:19])[C:20](=[O:22])[CH3:21]

Participants

5

Reactant 4

HCID 3939Lithium HydroxideHCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 54549905HCID 54549905, compound

Product 1

HCID 9927844HCID 9927844, compoundYield 43.4%

Procedure

2-[(2,6-Dichloro-3-methylphenyl)amino]-N-hydroxybenzenemethanamine (1.00 g, 3.4 mmol) is reacted with acetyl chloride (0.58 g, 7.4 mmol), triethylamine (1.0 g, 10.1 mmol), and lithium hydroxide (0.40 g, 16.8 mmol) according to the procedure of Example 48 to give 0.5 g (43% yield) of N-[[2-[(2,6-dichloro-3-methylphenyl)amino]phenyl]methyl]-N-hydroxyacetamide; mp 155°-156° C.

Sources & evidence

ORD record
ord-0e5391bb9240442c826b52a040813d16
Source dataset
uspto-grants-1992_05
Patent number
US05112846

Reaction notes

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