2-Acetyl-5-Methylfuran → Urea, N-hydroxy-N-[1-(5-methyl-2-furanyl)ethyl]-

HRID 1195907Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1195907
[C:1](=[N:9][OH:10])([C:3]1[O:4][C:5]([CH3:8])=[CH:6][CH:7]=1)[CH3:2].C(C1[O:15][C:16](C)=CC=1)(=O)C.Cl.[NH2:21]O>C(O)C.N1C=CC=CC=1.O>[OH:10][N:9]([CH:1]([C:3]1[O:4][C:5]([CH3:8])=[CH:6][CH:7]=1)[CH3:2])[C:16]([NH2:21])=[O:15]

Komponenten

7

Edukt 3

HCID 145142-Acetyl-5-MethylfuranHCID 443297Hydroxyamine hydrochlorideHCID 32890792-Acetyl-5-methylfuran oxime

Produkt 1

HCID 10487728Urea, N-hydroxy-N-[1-(5-methyl-2-furanyl)ethyl]-

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittelHCID 1049PyridineLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

2-Acetyl-5-methylfuran oxime. 2-Acetyl 5-methylfuran (5 g, 40.3 mmole) and hydroxylamine hydrochloride (4.2 g, 60.4 mmole) were dissolved in a mixture of ethanol (20mL) and pyridine (6.5 mL) and heated at 50° C. for 2 hours. The reaction mixture was diluted with water (300 mL) and extracted twice with ethyl acetate. The organic layer was washed with 2N HCl and brine, dried over MgSO4 and concentrated in vacuo to provided 4.31 g of the desired product.

Aufarbeitung

  1. extractionextracted twice with ethyl acetate
  2. washThe organic layer was washed with 2N HCl and brine
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-5dfd462817584daf86b7e9b66da6cb88
Quelldatensatz
uspto-grants-1992_05
Patentnummer
US05112848

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