Hydrochloric Acid → HCID 131717357, compound

HRID 1196161Notes

Reaction equation

HRID 1196161 reaction equation
COCO[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH:11](N(CC1C=CC=CC=1)C(C1C=CC=CC=1)C1C=CC=CC=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[O:18]COC.[NH2:43][CH:44]([C:51]1[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=1)[C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1.CC[O:59][CH2:60][CH3:61].[ClH:62]>C(OCC)(=O)C>[ClH:62].[OH:18][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=1[CH2:11][C:6]([CH2:7][C:8]1[CH:9]=[CH:10][CH:5]=[CH:61][C:60]=1[OH:59])([NH:43][CH:44]([C:45]1[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1)[C:51]1[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 7036BenzhydrylamineHCID 131717359HCID 131717359, compound

Product 1

HCID 131717357HCID 131717357, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

At first, 4.88 g of 2-[bis(methoxymethoxyphenyl)methyl-N-(diphenylmethyl)benzylamine was obtained in a similar manner as in Example 77, except that aminodiphenylmethane was used in place of cyclooctylamine. The compound was then dissolved in ethyl acetate saturated with hydrochloric acid. The mixture was stirred for 10 minutes, and then ether was added to the mixture. Precipitates were collected by filtration and then dried to afford 1.3 g of the desired compound of hydrochloride (Compound 87).

Workup

  1. customPrecipitates
  2. filtrationwere collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-f6461a161cdc45929056f9545254e63d
Source dataset
uspto-grants-1992_05
Patent number
US05112867

Reaction notes

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