反应详情

In 50 ml of tetrahydrofuran were dissolved 1.5 g of 1-(2-chlorophenyl)piperazine and 5 ml of triethylamine, and 3.4 g of 2-[bis(4-hydroxyphenyl)methyl]benzylbromide was added thereto. The mixture was heated under reflux for 3.5 hours, and then insoluble substances were filtered off. The filtrate was concentrated, and the residue was subjected to extraction with the addition of water and ethyl acetate. The organic layer was separated, and the aqueous layer was then extracted with ethyl acetate. The organic layers were combined and then dried over anhydrous magnesium sulfate. The solvent was evaporated off under reduced pressure, and the residue was purified by silica gel chromatography to afford 0.54 g of the desired compound (Compound 89).

1. additionwas added
2. temperatureThe mixture was heated
3. temperatureunder reflux for 3.5 hours
4. filtrationinsoluble substances were filtered off
5. concentrationThe filtrate was concentrated
6. extractionthe residue was subjected to extraction with the addition of water and ethyl acetate
7. customThe organic layer was separated
8. extractionthe aqueous layer was then extracted with ethyl acetate
9. dry with materialdried over anhydrous magnesium sulfate
10. customThe solvent was evaporated off under reduced pressure
11. customthe residue was purified by silica gel chromatography