反应详情

In 500 ml of methyl ethyl ketone were dissolved 50 g of phenolphthalin and 75 g of anhydrous potassium carbonate, and the solution was ice cooled. Subsequently, 58 ml of benzyl bromide was added dropwise to the solution, and the mixture was heated under reflux for 24 hours. The temperature of the mixture was brought back to room temperature, and concentrated. Thereafter, water was added to the residue, and the aqueous mixture was extracted with ethyl acetate. The organic layer was separated, and the aqueous layer was extracted with ethyl acetate. ]he organic layers were combined, washed with an aqueous 10% citric acid and then dried over anhydrous magnesium sulfate. The solvent was evaporated to give 114.61 g of the desired product.

1. temperaturecooled
2. temperaturethe mixture was heated
3. temperatureunder reflux for 24 hours
4. customwas brought back to room temperature
5. concentrationconcentrated
6. additionThereafter, water was added to the residue
7. extractionthe aqueous mixture was extracted with ethyl acetate
8. customThe organic layer was separated
9. extractionthe aqueous layer was extracted with ethyl acetate
10. washwashed with an aqueous 10% citric acid
11. dry with materialdried over anhydrous magnesium sulfate
12. customThe solvent was evaporated