Methyl iodide → HCID 67918424, compound

HRID 1196224Notes

Reaction equation

HRID 1196224 reaction equation
[CH3:1][C:2]([CH3:41])([O:4][C:5]([NH:7][NH:8][C:9]([C:11]1[CH:16]=[C:15]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:14]([O:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[C:13]([CH2:33][S:34][C:35]2[CH:40]=[CH:39][N:38]=[CH:37][CH:36]=2)[N:12]=1)=[O:10])=[O:6])[CH3:3].[CH3:42][I:43]>CN(C)C=O>[I-:43].[CH3:3][C:2]([CH3:41])([O:4][C:5]([NH:7][NH:8][C:9]([C:11]1[N:12]=[C:13]([CH2:33][S:34][C:35]2[CH:36]=[CH:37][N+:38]([CH3:42])=[CH:39][CH:40]=2)[C:14]([O:25][CH2:26][C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)=[C:15]([O:17][CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:16]=1)=[O:10])=[O:6])[CH3:1]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 57047250HCID 57047250, compound

Product 1

HCID 67918424HCID 67918424, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2.7 g of the compound of Example 20a and 1.3 g methyliodide were stirred in 30 ml dimethylformamide for 48 hours. Complete reaction by DC after that time. The dimethylformamide was distilled off and the residue stirred with ether yielding 3.3 g of the title compound, yellow solid. M.P.=192°-193° C. (dec).

Workup

  1. customComplete reaction by DC after that time
  2. distillationThe dimethylformamide was distilled off

Sources & evidence

ORD record
ord-01b2bb7a695846e4901c7ccfe09d9beb
Source dataset
uspto-grants-1992_05
Patent number
US05112968

Reaction notes

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