4-Methylmorpholine → HCID 178512170, compound

HRID 1196302Notes

Reaction equation

HRID 1196302 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:7]([NH:9][C@H:10]([C:20]([N:22]1[CH2:51][CH2:50][CH2:49][CH2:48][C@H:23]1[C:24]([NH:26][C@H:27]([C:38]([O:40][CH2:41][C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)=[O:39])[CH2:28][CH2:29][CH2:30][NH:31][C:32](=[NH:37])[NH:33][N+:34]([O-:36])=[O:35])=[O:25])=[O:21])[CH2:11][O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:8])[CH2:3][C:4](=[O:6])[NH2:5].Cl.CCOC(C)=O.CN1CCOCC1.[N:73]1([C:88]([O:90][CH2:91][C:92]2[CH:97]=[CH:96][CH:95]=[CH:94][CH:93]=2)=[O:89])[CH2:87][CH2:86][CH2:85][C@H:74]1[C:75]([O:77]N1C(=O)CCC1=O)=O>>[N:73]1([C:88]([O:90][CH2:91][C:92]2[CH:93]=[CH:94][CH:95]=[CH:96][CH:97]=2)=[O:89])[CH2:87][CH2:86][CH2:85][C@H:74]1[C:75]([NH:1][C@H:2]([C:7]([NH:9][C@H:10]([C:20]([N:22]1[CH2:51][CH2:50][CH2:49][CH2:48][C@H:23]1[C:24]([NH:26][C@H:27]([C:38]([O:40][CH2:41][C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)=[O:39])[CH2:28][CH2:29][CH2:30][NH:31][C:32](=[NH:37])[NH:33][N+:34]([O-:36])=[O:35])=[O:25])=[O:21])[CH2:11][O:12][CH2:13][C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)=[O:8])[CH2:3][C:4](=[O:6])[NH2:5])=[O:77]

Participants

5

Reactant 4

HCID 79724-MethylmorpholineHCID 8534821,2-Pyrrolidinedicarboxylic acid, 2-(2,5-dioxo-1-pyrrolidinyl) 1-(phenylmethyl) ester, (2S)-HCID 21866389Hydrogen chloride-ethyl acetateHCID 178454213HCID 178454213, compound

Product 1

HCID 178512170HCID 178512170, compound

Procedure

The desired compound was prepared from 0.68 g of Boc-Asn-Ser(Bzl)-Pip-Arg(NO2)-OBzl, 3 ml of 4N HCl-AcOEt, 0.14 ml of NMM and 0.32 g of Z-Pro-OSu in the same manner as in Example 12-(2).

Sources & evidence

ORD record
ord-d99cea40701d42eea0cbb008eb9e263c
Source dataset
uspto-grants-1992_05
Patent number
US05112947

Reaction notes

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