Chloromethyl Methyl Ether → HCID 19898300, compound

HRID 1196402Notes

Reaction equation

HRID 1196402 reaction equation
[F:1][CH:2]([F:33])[O:3][C:4]1[CH:9]=[C:8]([O:10][CH3:11])[N:7]=[C:6]([O:12][C:13]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][C:23]3[N:28]=[C:27]([O:29][CH3:30])[CH:26]=[C:25]([O:31][CH3:32])[N:24]=3)[C:14]=2[C:15]([OH:17])=[O:16])[N:5]=1.[H-].[Na+].Cl[CH2:37][O:38][CH3:39]>CN(C)C=O>[F:33][CH:2]([F:1])[O:3][C:4]1[CH:9]=[C:8]([O:10][CH3:11])[N:7]=[C:6]([O:12][C:13]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][C:23]3[N:24]=[C:25]([O:31][CH3:32])[CH:26]=[C:27]([O:29][CH3:30])[N:28]=3)[C:14]=2[C:15]([O:17][CH2:37][O:38][CH3:39])=[O:16])[N:5]=1

Participants

5

Reactant 3

HCID 7864Chloromethyl Methyl EtherHCID 24758Sodium hydrideHCID 19898302HCID 19898302, compound

Product 1

HCID 19898300HCID 19898300, compoundYield 82.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.9 g of (1.9 mmol) of 2-(4-difluoromethoxy-6-methoxypyrimidin-2-yl)oxy-6-(4,6-dimethoxypyrimidin-2-yl)oxybenzoic acid, 0.1 g of 60% sodium hydride and 0.2 g of chloromethylmethylether were reacted in N,N-dimethylformamide, treated and purified in the same manner as in Example 1 to obtain 0.8 g of a colorless transparent viscous liquid having a refractive index of nD20 =1.5389.

Workup

  1. additiontreated
  2. custompurified in the same manner as in Example 1

Sources & evidence

ORD record
ord-a8745619739d48cc84a3e4b22e12d51b
Source dataset
uspto-grants-1992_05
Patent number
US05114463

Reaction notes

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