反应详情

温度

90 °C

N-(3-chlorobenzyl)-N-(2-pentenyl)-2,2-dichloroacetamide was added by 1 g into 15 ml of xylene, to which 2 g of di-normal-butylamine and 0.5 g of cuprous chloride were added under stirring at 90° C. After continuing stirring for one hour, 40 ml of 20% hydrochloric acid was added and extracted with toluene. The extract was dried with anhydrous magnesium sulfate, concentrated by an evaporator and then purified on silica gel chromatography (hexane/ethyl acetate=3/1, v/v) to obtain 0.6 g of an oily product. This was a mixture of four isomers.

1. additionwere added
2. stirringAfter continuing stirring for one hour
3. extractionextracted with toluene
4. dry with materialThe extract was dried with anhydrous magnesium sulfate
5. concentrationconcentrated by an evaporator
6. custompurified on silica gel chromatography (hexane/ethyl acetate=3/1