Sodium Chloride → HCID 54367103, compound

HRID 1196405Notes

Reaction equation

HRID 1196405 reaction equation
[C:1](=O)([O-])[O-].[K+].[K+].[CH2:7]([NH2:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[CH2:15](Cl)[CH:16]=[CH:17][CH2:18][CH2:19][CH3:20].[Cl-].[Na+]>CN(C)C=O>[CH2:7]([NH:14][CH2:15][CH:16]=[CH:17][CH2:18][CH2:19][CH2:20][CH3:1])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

6

Reactant 4

HCID 5234Sodium ChlorideHCID 7504BenzylamineHCID 11430Potassium CarbonateHCID 5343541-Chlorohex-2-ene

Product 1

HCID 54367103HCID 54367103, compoundYield 94.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

13 g of potassium carbonate and 20 g of benzylamine were added to 25 ml of N,N-dimethylformamide and, further, 20 g of 2-hexenyl chloride was added and stirred at 100°-120° C. for one hour. After the reaction, 100 ml of an aqueous solution of sodium chloride was added, extracted with ethyl acetate and dried with anhydrous sodium sulfate. After concentration in an evaporator, it was subjected to silica gel column chromatography (hexane/ethyl acetate=1/1, v/v) to obtain 18 g of the aimed compound.

Workup

  1. additionwas added
  2. extractionextracted with ethyl acetate
  3. dry with materialdried with anhydrous sodium sulfate
  4. concentrationAfter concentration
  5. customin an evaporator, it

Sources & evidence

ORD record
ord-a3247e5bc47a46b4b4f3a25aaa41d0b9
Source dataset
uspto-grants-1992_05
Patent number
US05114466

Reaction notes

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