Dimethylformamide → N-[5-[2-(3-fluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-1-methyl-6-oxopyridazine-3-carboxamide

HRID 119663Notes

Reaction equation

HRID 119663 reaction equation
[CH3:23][n:24]1[n:25][c:26]([C:31](=[O:32])[OH:33])[cH:27][cH:28][c:29]1=[O:30].[CH:58]([N:59]([CH2:60][CH3:61])[CH:62]([CH3:63])[CH3:64])([CH3:65])[CH3:66].[F:1][c:2]1[cH:3][c:4]([CH:8]2[N:9]([c:13]3[n:14][c:15]4[n:16]([cH:17][cH:18]3)[n:19][cH:20][c:21]4[NH2:22])[CH2:10][CH2:11][CH2:12]2)[cH:5][cH:6][cH:7]1.[O:67]=[CH:68][N:69]([CH3:70])[CH3:71].[P-:34]([F:35])([F:36])([F:37])([F:38])([F:39])[F:40].[n:41]1([O:42][C:43]([N:44]([CH3:45])[CH3:46])=[N+:47]([CH3:48])[CH3:49])[c:50]2[n:51][cH:52][cH:53][cH:54][c:55]2[n:56][n:57]1>>[F:1][c:2]1[cH:3][c:4]([CH:8]2[N:9]([c:13]3[n:14][c:15]4[n:16]([cH:17][cH:18]3)[n:19][cH:20][c:21]4[NH:22][C:31]([c:26]3[n:25][n:24]([CH3:23])[c:29](=[O:30])[cH:28][cH:27]3)=[O:32])[CH2:10][CH2:11][CH2:12]2)[cH:5][cH:6][cH:7]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 23666951-Methyl-6-oxo-1,6-dihydropyridazine-3-carboxylic acidHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 673295365-[2-(3-Fluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-amine

Product 1

HCID 67331547N-[5-[2-(3-fluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-1-methyl-6-oxopyridazine-3-carboxamide

Sources & evidence

ORD record
ord-e25fde481b8143cf88c0ce4904d7ec8a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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