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HRID1196735

反应详情

EQUATION

反应方程式

HRID 1196735 的结构方程式

REACTANTS

反应物

4
结构：C(=NC1CCCCC1)=NC1CCCCC1
HCID10868

Dicyclohexylcarbodiimide

C13H22N2

结构：CC(C)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
HCID1549133

N-(9-Fluorenylmethoxycarbonyl)-L-leucine

C21H23NO4

结构：CC(C)(C)OC(=O)C[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O
HCID7018816

未命名化合物

结构：CC(C)C[C@H](NC(=O)[C@H](NC(=O)[C@@H]1CSCN1C(=O)[C@@H](CC(=O)OC(C)(C)C)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12)C(C)C)C(=O)O
HCID131717388

未命名化合物

PRODUCTS

生成物

2
结构：CC(C)C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]2CSCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O
HCID10508218

未命名化合物

结构：CC(C)C[C@H](NC(=O)[C@H](NC(=O)[C@@H]1CSCN1)C(C)C)C(=O)O
HCID131717387

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CN(C)c1ccncc1
催化剂HCID14284

N,N-Dimethylpyridin-4-amine

C7H10N2

结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Thz-DVal-Leu-resin which was prepared from Fmoc-Leu-resin in the same manner described in Example 4, was unpacked from a reaction column and allowed to react with 2.5 equivalents of the symmetrical acid anhydride of Fmoc-nAsp(OtBu)(prepared previously from Fmoc-DAsp(OtBu) and DCC) and DMAP(10 mg) in DMF at room temperature for 3 h with occasional shaking. After removal of excess reagents, the resin was washed successively with DMF, tert-amyl alcohol, acetic acid, tert-amyl alcohol and DMF, and repacked in a reaction column. The further solid-phase peptide synthesis was performed by the standard protocol described in Example 4. The resulting DTrp-DAsp(OtBu)-Thz-DVal-Leu-resin was treated in the same manner described in Example 4 to give the title compound.

WORKUP

后处理

  1. customwas unpacked from a reaction column
  2. customAfter removal of excess reagents
  3. washthe resin was washed successively with DMF, tert-amyl alcohol, acetic acid, tert-amyl alcohol and DMF
  4. customrepacked in a reaction column