Water → HCID 19896210, compound

HRID 1196770Notes

Reaction equation

HRID 1196770 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[N:9]1[C:14](=[O:15])[CH:13]=[C:12]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=2)[NH:11][C:10]1=[O:26].[C:27](=O)([O-])[O-].[K+].[K+].CI.O>CN(C)C=O>[CH3:27][N:11]1[C:12]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:23])[F:24])[CH:17]=2)=[CH:13][C:14](=[O:15])[N:9]([C:3]2[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=2[F:1])[C:10]1=[O:26]

Participants

6

Reactant 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 19896201HCID 19896201, compound

Product 1

HCID 19896210HCID 19896210, compoundYield 86.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

1.00 g of 3-(2-fluoro-4-chlorophenyl)-6-(3-trifluoromethylphenyl)-2,4(1H,3H)-pyrimidinedione was dissolved in 10 ml of dimethylformamide, followed by addition of 0.48 g of anhydrous potassium carbonate and 0.48 g of methyl iodide, and stirring of the solution at room temperature for 4 hours. The resulting reaction solution was poured into water and the precipitated crystals were filtered out and dried to obtain 0.90 g of the objective compound.

Workup

  1. customThe resulting reaction solution
  2. filtrationthe precipitated crystals were filtered out
  3. customdried

Sources & evidence

ORD record
ord-27fa550ae8554bb1bc99c081abdb8873
Source dataset
uspto-grants-1992_05
Patent number
US05116404

Reaction notes

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