Water → HCID 53940263, compound

223.12 g (1 mol) of ethyl 6-bromohexanoate and 275.4 g (1.05 mol) of triphenyl phosphine were refluxed for 36 hours in 1.5 l of acetonitrile. After the reaction was terminated, 500 ml of acetonitrile was distilled off, then the reaction mixture was dried. Into the dried mixture, 72.11 g (1 mol) of isobutyl aldehyde was added and stirred. Controlling the reaction temperature in the range of 25°-35° C., 40 g (1 mol) of oily (60%) sodium hydride was carefully added. Then, the reaction mixture was stirred over night at room temperature. After the reaction was ended, 500 g of water was added into the reaction mixture, the oil layer was then separated and the water layer was extracted twice with 300 ml of hexane. The organic layers were combined and washed with 300 ml of water, solvent was removed in vacuum under reduced pressure, and then distilled under 2 mm Hg to obtain 122.8 g of ethyl 8-methyl-6-nonenoate (Yield: 62% based upon the starting material).

1. customAfter the reaction was terminated
2. distillation500 ml of acetonitrile was distilled off
3. customthe reaction mixture was dried
4. additionwas carefully added
5. stirringThen, the reaction mixture was stirred over night at room temperature
6. customthe oil layer was then separated
7. extractionthe water layer was extracted twice with 300 ml of hexane
8. washwashed with 300 ml of water, solvent
9. customwas removed in vacuum under reduced pressure
10. distillationdistilled under 2 mm Hg

ORD record

ord-5b4fc81ab9d04fb48250514c911a55cb

Source dataset

uspto-grants-1992_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05116813