4-Methoxybenzaldehyde → HCID 136153535, compound

HRID 1196882Notes

Reaction equation

HRID 1196882 reaction equation
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([CH:7]=O)=[CH:5][CH:4]=1.S([O-])(O)=O.[Na+].[NH2:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][C:26]=1[NH2:27])[N:23]=[CH:22][NH:21][C:20]2=[O:28]>CO>[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]2[NH:16][C:17]3=[CH:18][C:19]4[C:20](=[O:28])[NH:21][CH:22]=[N:23][C:24]=4[CH:25]=[C:26]3[N:27]=2)=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 312444-MethoxybenzaldehydeHCID 23665763Sodium BisulfiteHCID 136066310HCID 136066310, compound

Product 1

HCID 136153535HCID 136153535, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a manner analogous to that described in Example 20, from 4-methoxy-benzaldehyde, sodium hydrogen sulphite and 6,7-diamino-3,4-dihydroquinazolin-4-one (see Example 2), after boiling with methanol, there was obtained the title compound in a yield of 82% of theory; m.p. >300° C.

Sources & evidence

ORD record
ord-1f0257e21f1e484da0658cc2623b3e4f
Source dataset
uspto-grants-1992_05
Patent number
US05116843

Reaction notes

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