1-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone → HCID 18956539, compound

HRID 1196927Notes

Reaction equation

HRID 1196927 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][N:6]=[N:5][CH:4]=1)[CH3:2].C([N-]C(C)C)(C)C.[Li+].[Cl:17][C:18]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:19]=1[C:25](=[O:32])[CH2:26][N:27]1[CH:31]=[N:30][CH:29]=[N:28]1>O1CCCC1>[Cl:17][C:18]1[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:19]=1[C:25]([OH:32])([CH:1]([C:3]1[CH:8]=[CH:7][N:6]=[N:5][CH:4]=1)[CH3:2])[CH2:26][N:27]1[CH:31]=[N:30][CH:29]=[N:28]1

Participants

5

Reactant 3

HCID 7393741-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanoneHCID 2724682Lithium diisopropylamideHCID 18956526HCID 18956526, compound

Product 1

HCID 18956539HCID 18956539, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Treatment of 4-ethylpyridazine (2.16 g) with lithium diisopropylamide (0.02 mole) in dry tetrahydrofuran followed by 1-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone (5.12 g) according to the method of Example 9(ii) gave the title compound, diastereoisomeric pair A, (1.24 g), m.p. 174°-177°;

Sources & evidence

ORD record
ord-447e84e73cce4fff8ac12b3b409814bf
Source dataset
uspto-grants-1992_05
Patent number
US05116844

Reaction notes

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