Diethyl Ether → HCID 18956540, compound

HRID 1196930Notes

Reaction equation

HRID 1196930 reaction equation
[CH3:1][C:2]1[N:3]=[N:4][CH:5]=[CH:6][CH:7]=1.C([N-]C(C)C)(C)C.[Li+].[F:16][C:17]1[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:18]=1[C:19](OC)=[O:20].CCOCC>O1CCCC1>[F:16][C:17]1[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:18]=1[C:19](=[O:20])[CH2:1][C:2]1[N:3]=[N:4][CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 3283Diethyl EtherHCID 742083-MethylpyridazineHCID 2724682Lithium diisopropylamideHCID 2782897Methyl 2,4-Difluorobenzoate

Product 1

HCID 18956540HCID 18956540, compoundYield 29.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Treatment of 3-methylpyridazine (4.70 g) with lithium diisopropylamide (0.05 mole) in dry tetrahydrofuran followed by methyl 2,4-difluorobenzoate (8.60 g) according to the method of Example 11(i) gave the title compound, (3.40 g), m.p. 115.5°-117.5° (from ether).

Sources & evidence

ORD record
ord-916598af6fc84fc9af8632cc48edcf89
Source dataset
uspto-grants-1992_05
Patent number
US05116844

Reaction notes

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