反应详情

温度

150 °C

In this example, 348.9 g of sodium salt of methyl p-hydroxybenzoate, 402.4 g of phthalide and 200 g of sodium chloride are mixed with one another and stirred at 150° C. for 6 hours. After completion of the reaction, the mixture is cooled until the temperature is brought back to room temperature, 4 l of aqueous 10% acetic acid solution is added thereto and the mixture is allowed to stand at room temperature overnight. After stirring the mixture at room temperature for 3 hours, deposited crystals are separated by filtration, and 6 l of water is added thereto. After stirring the mixture at room temperature for 30 minutes, the deposited crystals are separated by filtration. After the addition of 3 l of toluene to the crystals, the mixture is stirred at room temperature for one hour. The crystals are separated by filtration and dried over heating under reduced pressure to yield 393.9 g of 2-(4-methoxycarbonylphenoxy) methyl benzoic acid.

1. customAfter completion of the reaction
2. temperaturethe mixture is cooled until the temperature
3. customis brought back to room temperature
4. waitto stand at room temperature overnight
5. stirringAfter stirring the mixture at room temperature for 3 hours
6. customare separated by filtration, and 6 l of water
7. additionis added
8. stirringAfter stirring the mixture at room temperature for 30 minutes
9. customthe deposited crystals are separated by filtration
10. additionAfter the addition of 3 l of toluene to the crystals
11. stirringthe mixture is stirred at room temperature for one hour
12. customThe crystals are separated by filtration
13. customdried
14. temperatureover heating under reduced pressure