Hydrochloric Acid → HCID 178418600, compound

HRID 1197076Notes

Reaction equation

HRID 1197076 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:9])[NH2:8].Cl.CO.C(O)(C)C>Cl.CC(O)=O>[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:8])[NH2:9]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 3776IsopropanolHCID 178454187HCID 178454187, compound

Product 1

HCID 178418600HCID 178418600, compoundYield 74.3%

Reagents, catalysts & solvents 1

HCID 22641269Acetate-hydrochloric acidSolvent

Procedure

BOC-Arg-CHA.HCl, 243.7 g (0.55 mole), was dissolved in 1093 ml of 2N HCl/AcOH and a small amount of MeOH. The solution was reacted at room temperature for an hour. After completion of the reaction, 1093 ml of isopropanol was added to the reaction mixture to cause precipitation again in AcOEt. The precipitated crystals were taken by filtration and dried to give 156.2 g (74.3%) of H-Arg-CHA.2HCl.

Workup

  1. customThe solution was reacted at room temperature for an hour
  2. additionwas added to the reaction mixture
  3. customprecipitation again in AcOEt
  4. filtrationThe precipitated crystals were taken by filtration
  5. customdried

Sources & evidence

ORD record
ord-311334d274ef49abbc20d8cda50d5a49
Source dataset
uspto-grants-1992_05
Patent number
US05116941

Reaction notes

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