Hydrochloric Acid → HCID 178512899, compound

HRID 1197078Notes

Reaction equation

HRID 1197078 reaction equation
[NH:1](C(OC(C)(C)C)=O)[CH2:2][C:3]([NH:5][C@H:6]([C:14]([OH:16])=[O:15])[CH2:7][CH2:8][CH2:9][NH:10][C:11](=[NH:13])[NH2:12])=[O:4].Cl.Cl.CC(O)=O>CO>[NH2:1][CH2:2][C:3]([NH:5][C@H:6]([C:14]([OH:16])=[O:15])[CH2:7][CH2:8][CH2:9][NH:10][C:11](=[NH:12])[NH2:13])=[O:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 22641269Acetate-hydrochloric acidHCID 178453838HCID 178453838, compound

Product 1

HCID 178512899HCID 178512899, compoundYield 189.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

After 125.7 g (0.25 mol) of BOC-Gly-Arg-CHA.HCl was dissolved in a small amount of MeOH, 500 ml (0.10 mol) of 2N HCl/AcOH was added to the solution. The mixture was reacted at room temperature for an hour with stirring. After completion of the reaction, the reaction mixture was reprecipitated in 4.5 liters of ether. The precipitated crystals were taken by filtration and dried to give 109.8 g (100%) of H-Gly-Arg-CHA.2HCl.

Workup

  1. additionwas added to the solution
  2. customThe mixture was reacted at room temperature for an hour
  3. customAfter completion of the reaction
  4. customthe reaction mixture was reprecipitated in 4.5 liters of ether
  5. filtrationThe precipitated crystals were taken by filtration
  6. customdried

Sources & evidence

ORD record
ord-f80f589ea58a42d2af9cbabfdb2c9265
Source dataset
uspto-grants-1992_05
Patent number
US05116941

Reaction notes

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