反应详情

A solution of 5-chloro-2-nitrophenol (7 g) in dimethylformamide (40 ml) was stirred at room temperature with 1-bromo-2-phenyl-2-propene (8 ml) and potassium carbonate (5.5 g) for 18 h. The reaction mixture was diluted with water (200 ml) was extracted with ether (100 ml). The ether was washed with water (3×100 ml). The solvent was removed under reduced pressure and the residue was crystallized from hexanes. The yellow solid (8.6 g) was the desired product. m.p. 74.5°-75.5° C.

1. extractionwas extracted with ether (100 ml)
2. washThe ether was washed with water (3×100 ml)
3. customThe solvent was removed under reduced pressure
4. customthe residue was crystallized from hexanes