反应详情

A mixture of phenylhydrazine (25 ml, 0.25 mmole) and triethylamine (35 ml, 0.25 mmole) in anhydrous ether (500 ml) was cooled down to -5° to -10° C. (ice-salt bath) under nitrogen and treated dropwise, over a 30 minute period, with 4-fluorobenzene carbonyl chloride (30 ml, 0.25 mole). The reaction mixture was warmed to room temperature, stirred for 3.0 hours, then filtered, washing the solids well with ether (200 ml). The solids were dissolved in dichloromethane (600 ml), stripped to near dryness, suspended in hexane (600 ml) and filtered. The clear filtrate was evaporated to dryness, triturated with tetrahydrofuran (700 ml) and filtered, washing the solids well with tetrahydrofuran (100 ml). The filtrate was evaporated to dryness and dried in vacuo to give a crude product (34.6 g) contaminated with two other components.

1. filtrationfiltered
2. washwashing the solids well with ether (200 ml)
3. dissolutionThe solids were dissolved in dichloromethane (600 ml)
4. filtrationfiltered
5. customThe clear filtrate was evaporated to dryness
6. customtriturated with tetrahydrofuran (700 ml)
7. filtrationfiltered
8. washwashing the solids well with tetrahydrofuran (100 ml)
9. customThe filtrate was evaporated to dryness
10. customdried in vacuo