Triethylamine → HCID 15657669, compound

HRID 1197532Notes

Reaction equation

HRID 1197532 reaction equation
[CH3:1][C:2]1([CH3:19])[CH2:15][CH:14]2[C:9](C(O)=O)([CH2:10][CH2:11][CH2:12][CH2:13]2)[C:8]2[C:3]1=[CH:4][CH:5]=[CH:6][CH:7]=2.C1(P(N=[N+]=[N-])(C2C=CC=CC=2)=[O:27])C=CC=CC=1.C([N:39]([CH2:42]C)CC)C>C1(C)C=CC=CC=1>[N:39]([C:9]12[C:8]3[C:3](=[CH:4][CH:5]=[CH:6][CH:7]=3)[C:2]([CH3:1])([CH3:19])[CH2:15][CH:14]1[CH2:13][CH2:12][CH2:11][CH2:10]2)=[C:42]=[O:27]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 199401P,P-Diphenylphosphinic azideHCID 19107075HCID 19107075, compound

Product 1

HCID 15657669HCID 15657669, compoundYield 86.5%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of the compound from Example 44 (0.62 g, 2.4 mmol) and diphenylphosphorylazide (0.73 g, 2.64 mmol) in triethylamine (0.36 g) and 10 ml toluene was refluxed at 110° C. for 30 minutes. Workup and purification on silica gel gave the title compound (0.53 g, 86%).

Workup

  1. customWorkup and purification on silica gel

Sources & evidence

ORD record
ord-53a87b4c40e24b06854b00535ef66862
Source dataset
uspto-grants-1994_01
Patent number
US05276053

Reaction notes

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