HCID 19107104, compound → HCID 19107020, compound

HRID 1197534Notes

Reaction equation

HRID 1197534 reaction equation
[O:1]=[C:2]1[CH2:15][CH:14]2[C:9]([C:16]([O:18]C)=[O:17])([CH2:10][CH2:11][CH2:12][CH2:13]2)[C:8]2[C:3]1=[CH:4][CH:5]=[CH:6][CH:7]=2.C[Si](C)(C)[O-].[K+]>C1COCC1>[O:1]=[C:2]1[CH2:15][CH:14]2[C:9]([C:16]([OH:18])=[O:17])([CH2:10][CH2:11][CH2:12][CH2:13]2)[C:8]2[C:3]1=[CH:4][CH:5]=[CH:6][CH:7]=2

Participants

4

Reactant 2

HCID 19107104HCID 19107104, compoundHCID 23668039Potassium trimethylsilanolate

Product 1

HCID 19107020HCID 19107020, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of the compound from Example 51 (1.5 g, 5.8 mmol) and potassium trimethylsilanolate (1.5 g, 11.6 mmol) in 25 ml THF was refluxed 60 hours. Workup as before and chromatography on silica gel gave the title compound (1.1 g, 78%).

Sources & evidence

ORD record
ord-5027bedf73bf4e1bb8d755ac76aa0b37
Source dataset
uspto-grants-1994_01
Patent number
US05276053

Reaction notes

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