反应详情

A mixture of the compound from Example 6 (10 g, 44 mmol) and sodium bicarbonate (4 g, 48 mmol) in 150 ml water was heated on a steam bath until a solution was obtained. Potassium iodide (14.6 g, 88 mmol) and iodine (22.4 g, 88 mmol) were dissolved in 150 ml water and added to the reaction mixture via an addition funnel. The reaction mixture was placed in a separatory funnel and shaken with sodium bisulfite and then extracted with methylene chloride. The organic phase was dried over sodium sulfate, filtered and evaporated to give the title compound as a yellow solid (13.7 g, 88% yield).

1. temperaturewas heated on a steam bath until a solution
2. customwas obtained
3. additionadded to the reaction mixture via an addition funnel
4. customThe reaction mixture was placed in a separatory funnel
5. extractionextracted with methylene chloride
6. dry with materialThe organic phase was dried over sodium sulfate
7. filtrationfiltered
8. customevaporated