Hydrochloric Acid → HCID 178502022, compound

HRID 1197844Notes

Reaction equation

HRID 1197844 reaction equation
[NH2:1][CH:2]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:3]1[CH:16]=[CH:15][C:6]2[NH:7][C:8]([NH:10][C:11](=[O:14])[O:12][CH3:13])=[N:9][C:5]=2[CH:4]=1.[ClH:23]>O>[ClH:23].[ClH:23].[NH2:1][CH:2]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:3]1[CH:16]=[CH:15][C:6]2[NH:7][C:8]([NH:10][C:11](=[O:14])[O:12][CH3:13])=[N:9][C:5]=2[CH:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178502021HCID 178502021, compound

Product 1

HCID 178502022HCID 178502022, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Methyl (±)-[5-(aminophenylmethyl)-1H-benzimidazol-2-yl]carbamate (1 g) was suspended in water (5 mL). To this mixture was added aqueous HCl (12N) with stirring to adjust the pH to ph ~2. As stirring was continued the hydrochloride salt precipitated from the solution. The mixture was cooled in an ice bath and the title product as a precipitate was collected by filtration, m.p.>300° C. Yield: 1.05 g (ca. 85%).

Workup

  1. stirringAs stirring
  2. customprecipitated from the solution
  3. temperatureThe mixture was cooled in an ice bath
  4. filtrationthe title product as a precipitate was collected by filtration, m.p.>300° C

Sources & evidence

ORD record
ord-ee556f75cc924584ac04e1f6216f61a5
Source dataset
uspto-grants-1994_01
Patent number
US05278181

Reaction notes

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