Phenylacetic Acid → 2-Phenylpropionic acid

HRID 1198007Notes

Reaction equation

[C:1]1([CH2:7][C:8]([OH:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:11](=O)(OC)OC.C([O-])([O-])=O.[K+].[K+]>>[C:1]1([CH:7]([CH3:11])[C:8]([OH:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

Reactant 3

HCID 999Phenylacetic Acid

HCID 11430Potassium Carbonate

HCID 12021Dimethyl Carbonate

Product 1

HCID 102962-Phenylpropionic acid

Procedure

α-Phenylmethylpropionate can be obtained under similar conditions, by reacting a mixture of phenylacetic acid, dimethyl carbonate and K2CO3, in a 1:20:2 molar ratio, in autoclave at a temperature of 225° C., for 15 hours.

Sources & evidence

ORD record: ord-d8ef46b38aaf432c8e44a7e6b368ad93
Source dataset: uspto-grants-1994_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05278333

Reaction notes

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