Triethylamine → HCID 10422730, compound

HRID 1198036Notes

Reaction equation

HRID 1198036 reaction equation
[C:1]1([C:7]2([C:12]([OH:14])=O)[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N1C=CN=C1)(N1[CH:21]=[CH:20]N=C1)=O.[Cl-].[Mg+2].[Cl-].C(O)(=O)[CH2:31][C:32]([OH:34])=[O:33].C([K])C.C(N(CC)CC)C>>[CH2:20]([O:34][C:32](=[O:33])[CH2:31][C:12](=[O:14])[C:7]1([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[CH2:8][CH2:9][CH2:10][CH2:11]1)[CH3:21]

Participants

6

Reactant 5

HCID 8471TriethylamineHCID 661671-Phenylcyclopentanecarboxylic acidHCID 682631,1'-CarbonyldiimidazoleHCID 5360315Magnesium ChlorideHCID 178461627HCID 178461627, compound

Product 1

HCID 10422730HCID 10422730, compound

Procedure

The title compound was prepared from 1-phenyl-1-cyclopentanecarboxylic acid (50.0 g, 0.220 mol), 1,1'-carbonyldiimidazole (43.0 g, 0.265 mol), magnesium chloride (40.0 g, 0.418 mol), ethyl potassium malonate (60.0 g, 0.352 mol), and triethylamine (48.9 g, 0.484 mol) using the procedure described in Example 3, Step A.

Sources & evidence

ORD record
ord-b58da569ef7a413ca3c57ca8e5249cc1
Source dataset
uspto-grants-1994_01
Patent number
US05278326

Reaction notes

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