Hexadecan-2-one → HCID 10366149, compound

HRID 1198052Notes

Reaction equation

[CH3:1][C:2](=[O:17])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[CH:18]([C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([CH:27]([CH3:29])[CH3:28])[C:22]=1[N:30]=[C:31]=[O:32])([CH3:20])[CH3:19].C([N-]C(C)C)(C)C.[Li+]>>[CH3:20][CH:18]([C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([CH:27]([CH3:28])[CH3:29])[C:22]=1[NH:30][C:31](=[O:32])[CH2:1][C:2](=[O:17])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])[CH3:19]

Participants

Reactant 3

HCID 29251Hexadecan-2-one

HCID 922592,6-Diisopropylphenyl isocyanate

HCID 2724682Lithium diisopropylamide

Product 1

HCID 10366149HCID 10366149, compound

Procedure

The title compound was prepared from 2-hexadecanone (5.0 g, 0.018 ml), 2,6-diisopropylphenyl isocyanate (3.72 g, 0.018 mol), and lithium diisopropylamide (0.018 mol) using the procedure described in Example 1. The desired product was obtained in 80% yield (6.38 g, 0.014 mol). MS: 443 (M+).

Sources & evidence

ORD record: ord-88407132d23747e6b7dd8cb5b7ebc263
Source dataset: uspto-grants-1994_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05278326

Reaction notes

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