Ethyl Acetate → (R)-1-(benzo[b]thiophen-5-yl)-2-bromoethanol

Temperature

-25 °C

A solution of 7.5 g of (+)-diisopinocamphenylchloroborane dissolved in 15 ml of tetrahydrofuran was cooled to -25° C. Thereto was added 4 g of 5-bromoacetylbenzo[b]thiophene. The resulting mixture was stirred for 4 hours at -20° C. to -15° C. The reaction mixture was added to a mixture of 80 ml of ethyl acetate and 80 ml of ice water. The organic layer was separated, washed with water and a saturated aqueous sodium chloride solution in this order, and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure The residue thus obtained was purified by column chromatography (eluant: hexane:ethyl acetate=10:1) to obtain 3.8 of (R)-1-(benzo[b]thiophen-5-yl)-2-bromoethanol.

1. customThe organic layer was separated
2. washwashed with water
3. dry with materiala saturated aqueous sodium chloride solution in this order, and dried over anhydrous magnesium sulfate
4. customThe solvent was removed by distillation under reduced pressure The residue
5. customthus obtained
6. customwas purified by column chromatography (eluant: hexane:ethyl acetate=10:1)

ORD record

ord-15ee4d60fc654426afbf0c5f0f09a5bf

Source dataset

uspto-grants-1994_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05280032