Dimethylamine → 2-Amino-4-dimethylamino-6-trifluoromethoxy-1,3,5-triazine

HRID 1198288Notes

Reaction equation

HRID 1198288 reaction equation
[CH3:1][NH:2][CH3:3].[NH2:4][C:5]1[N:10]=[C:9](F)[N:8]=[C:7]([O:12][C:13]([F:16])([F:15])[F:14])[N:6]=1>O1CCCC1>[NH2:4][C:5]1[N:10]=[C:9]([N:2]([CH3:3])[CH3:1])[N:8]=[C:7]([O:12][C:13]([F:16])([F:15])[F:14])[N:6]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 150103882-Amino-4-fluoro-6-trifluoromethoxy-1,3,5-triazin

Product 1

HCID 150103992-Amino-4-dimethylamino-6-trifluoromethoxy-1,3,5-triazine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
22 °C

Procedure

5.0 g (0.111 mol) of dimethylamine were passed over the course of 20 minutes into a stirred solution of 11 g (0.055 mol) of 2-amino-4-fluoro-6-trifluoromethoxy-1,3,5-triazine in 150 ml of tetrahydrofuran at 0° C. The mixture was stirred at 0° C. for one hour and at 22° C. overnight. Concentration, washing with water and drying yielded 9.9 g (80.7% of theory) of the title compound of melting point 114°-118° C. (decomposition).

Workup

  1. concentrationConcentration
  2. washwashing with water
  3. customdrying

Sources & evidence

ORD record
ord-677b97ff6545471694672c1b17f2e501
Source dataset
uspto-grants-1994_01
Patent number
US05280118

Reaction notes

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