Hydrochloric Acid → HCID 19102600, compound

HRID 1198554Notes

Reaction equation

HRID 1198554 reaction equation
O[CH:2]([C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][CH:28]=1)[C:24]#[N:25])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5](/[CH:9]=[CH:10]/[C:11]2[CH:20]=[CH:19][C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:12]=2)[CH:4]=1.[ClH:29]>ClCCl.O.C(=O)(O)[O-].[Na+]>[Cl:29][CH:2]([C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][CH:28]=1)[C:24]#[N:25])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5](/[CH:9]=[CH:10]/[C:11]2[CH:20]=[CH:19][C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:12]=2)[CH:4]=1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 19102561HCID 19102561, compound

Product 1

HCID 19102600HCID 19102600, compound

Reagents, catalysts & solvents 3

HCID 962WaterSolventHCID 6344DichloromethaneSolventHCID 516892Sodium BicarbonateSolvent

Procedure

A suspension of the 3-[α-hydroxy-3-{2(E)-(quinolin-2-yl)ethenyl}benzyl]benzonitrile (1.4 g, 3.87 mmol) in dichloromethane (75 ml) was stirred with concentrated hydrochloric acid (75 ml) for 3 hours, diluted with water and neutralised with saturated sodium bicarbonate solution. The aqueous layer was extracted with further dichloromethane and the combined solvent was dried and evaporated to a pale solid.

Workup

  1. extractionThe aqueous layer was extracted with further dichloromethane
  2. customthe combined solvent was dried
  3. customevaporated to a pale solid

Sources & evidence

ORD record
ord-360929579fdd4ce9b7ac41bbd63c71c6
Source dataset
uspto-grants-1994_01
Patent number
US05281593

Reaction notes

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